Inclusion complexes of poorly water-soluble drugs with glucosyl-cyclodextrins.

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Inclusion complexes of poorly water-soluble drugs with glucosyl-cyclodextrins.

glucosyl-ƒ¿-CD (G-ƒ¿-CD), 6-O-ƒ¿-D-glucosyl-ƒÀ-CD (G-ƒÀ-CD), and 6A,6D-di-O-ƒ¿-D-glucosyl-ƒÀ-CD (2G-ƒÀ-CD) with slightly soluble or insoluble drugs in aqueous solution and in the solid state was studied by the solubility method, ultraviolet spectroscopy, and differential scanning calorimetry. These glucosyl-CDs were capable of forming inclusion complexes with compounds which can form complexes ...

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ژورنال

عنوان ژورنال: Chemical and Pharmaceutical Bulletin

سال: 1987

ISSN: 0009-2363,1347-5223

DOI: 10.1248/cpb.35.3413